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In the ACHIEVE-1 phase 3 trial, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with early type 2 diabetes.

ASCO GI 2026 Insights: GLP-1 Receptor Agonist vs. Aspirin for Primary Prevention of CRC - Evidence From a Real-World Head-to-Head Comparison

Unlocking the broad health benefits and risks of GLP-1 receptor agonist drugs | Nature Medicine

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